In real trouble the time afterwards (5)
I believe the answer is:
later
'afterwards' is the definition.
(I know that afterwards can be written as later)
'in real trouble the time' is the wordplay.
'in' indicates putting letters inside.
'trouble' indicates an anagram.
'the time' becomes 't' (abbreviation).
'real' is an anagram of 'laer'.
'laer' placed around 't' is 'LATER'.
(Other definitions for later that I've seen before include "at a future date" , "after the rest?" , "When to see you?" , "Tardier" , "Following" .)