In the distance, canter off making commercial (10)
I believe the answer is:
mercantile
'commercial' is the definition.
(similar in meaning)
'in the distance canter off' is the wordplay.
'in' indicates putting letters inside.
'the distance' becomes 'mile'.
'off' indicates anagramming the letters.
'canter' is an anagram of 'ercant'.
'mile' enclosing 'ercant' is 'MERCANTILE'.
'making' acts as a link.
(Other definitions for mercantile that I've seen before include "concerning trade" , "Commercial" , "Relating to trade or commerce" , "related to business" , "Dealing with trade" .)