In the morning, is drop of spirits wrong? (5)
I believe the answer is:
amiss
'wrong?' is the definition.
(synonyms)
'in the morning is drop of spirits' is the wordplay.
'in the morning' becomes 'am' (AM on a clock).
'drop of' suggests taking the first letters (the smallest possible amount of the word).
The first letter of 'spirits' is 's'.
'am'+'is'+'s'='AMISS'
(Other definitions for amiss that I've seen before include "(Gone) wrong" , "Mistakenly" , "Out of order" , "Wrong (a girl!)" , "Badly - wrong" .)