Inclined to accept Republican is well-informed (7)
I believe the answer is:
learned
'well-informed' is the definition.
(thesaurus)
'inclined to accept republican' is the wordplay.
I cannot quite understand how this works, but
'republican' could be 'r' (abbreviation in US politics) and 'r' is present in the answer.
'inclined' could be 'leaned' ('lean' can be a synonym of 'incline') and 'leaned' is present in the remaining letters.
No letters remain.
This explanation may well be incorrect...
'is' acts as a link.
Can you help me to learn more?
(Other definitions for learned that I've seen before include "Came to know" , "Highly educated" , "Got to know" , "Well educated and knowledgeable" , "Discovered - erudite" .)