Indicates wine is over (8)
I believe the answer is:
portends
'indicates' is the definition.
(portending is a kind of indicating)
'wine is over' is the wordplay.
'wine' becomes 'port' (port is a kind of wine).
'is over' becomes 'ends' ().
'port'+'ends'='PORTENDS'
(Other definitions for portends that I've seen before include "Gives warning" , "Signals" , "Augurs, bodes" , "Indicates by signs" , "Warns" .)