Indication of resignation? (4)
I believe the answer is:
sign
'indication' is the definition.
(I know that indication can be written as sign)
'of resignation?' is the wordplay.
'of' indicates the answer is hidden within the clue.
'SIGN' can be found hidden inside 'resignation'.
(Other definitions for sign that I've seen before include "Public display of a message" , "part of the zodiac" , "Augury" , "house" , "Evidence" .)