Indigenous American's uncle? (6)
I believe the answer is:
pawnee
This clue could be a double definition.
'indigenous american's' is the first definition.
'Pawnee' can be an answer for 'american's' (Pawnee is an example). I'm unsure of the 'indigenous' bit.
'uncle?' is the second definition.
The definition and answer can be both people as well as being singular nouns.
Perhaps you can see a link between them that I can't see?
(Other definitions for pawnee that I've seen before include "North American Indian - one taking a pledge" , "N American native" , "one living in America" .)