Individual taking on everything (8)
I believe the answer is:
entirety
'everything' is the definition.
(thesaurus)
'individual taking on' is the wordplay.
'individual' becomes 'entity' (I can't explain this - if you can you should give a lot more credence to this answer).
'taking' is an insertion indicator.
'on' becomes 're' ('on' can be mean 'with reference to').
'entity' enclosing 're' is 'ENTIRETY'.
Can you help me to learn more?
(Other definitions for entirety that I've seen before include "Universe" , "Totality" , "The lot" , "Sum" , "Absoluteness" .)