Infilling suspect cavity (5)
I believe the answer is:
sinus
'cavity' is the definition.
(I know that sinus is a type of cavity)
I cannot understand how the rest of the clue works.
(Other definitions for sinus that I've seen before include "Hollow space" , "Cavity linked to nose" , "snotty enclosure" , "Head space" , "Cavity in skull connecting with nostrils" .)