Influential reply twisted round, for the most part (13)
I believe the answer is:
predominantly
'for the most part' is the definition.
(I've seen this before)
'influential reply twisted round' is the wordplay.
'influential' becomes 'dominant' (I can't justify this - if you can you should believe this answer much more).
'twisted' is an anagram indicator.
'round' is an insertion indicator.
'reply' is an anagram of 'prely'.
'dominant' put within 'prely' is 'PREDOMINANTLY'.
Can you help me to learn more?
(Other definitions for predominantly that I've seen before include "Mainly; prominent lady (anag.)" , "In the main" , "Mostly" , "For the most part" , "Chiefly" .)