Informal road is a nuisance (4)
I believe the answer is:
drag
This clue might be a double definition.
'informal road' is the first definition.
'drag' can be an answer for 'road' (thesaurus). I am not certain of the 'informal' bit.
'nuisance' is the second definition.
(thesaurus)
'is a' acts as a link.
Can you help me to learn more?
(Other definitions for drag that I've seen before include "pain" , "Short smoke" , "Become tedious" , "Haul - a bore!" , "Yank" .)