Informs one about every setback (7)
I believe the answer is:
teaches
'informs' is the definition.
(teaching is a kind of informing)
'one about every setback' is the wordplay.
'one about' is an insertion indicator.
'every' becomes 'each' ('each' can be a synonym of 'every').
'setback' becomes 'tes' (I've seen this in other clues).
'each' placed inside 'tes' is 'TEACHES'.
(Other definitions for teaches that I've seen before include "Trains" , "Instructs" .)