Initially stuffy wife has urge to change (6)
I believe the answer is:
switch
'change' is the definition.
(switch is a kind of change)
'initially stuffy wife has urge' is the wordplay.
'initially' indicates taking the first letters.
'has' says to put letters next to each other.
'urge' becomes 'itch' (I've seen this before**).
The initial letters of 'stuffy wife' is 'sw'.
'sw'+'itch'='SWITCH'
'to' acts as a link.
(Other definitions for switch that I've seen before include "Circuit-breaker" , "On/off device" , "Sudden quick change" , "that turns on the power" , "Light whip - light control" .)