Initiative key with force (10)
I believe the answer is:
enterprise
'initiative' is the definition.
('enterprise' can be a synonym of 'initiative')
'key with force' is the wordplay.
'key' becomes 'enter' (key on a computer keyboard).
'with' means one lot of letters go next to another.
'force' becomes 'prise' (I've seen this before**).
'enter'+'prise'='ENTERPRISE'
(Other definitions for enterprise that I've seen before include "Bold resourcefulness" , "audacity" , "drug business" , "Plan" , "Initiative - undertaking - business" .)