Initiative required to go in and pry (10)
I believe the answer is:
enterprise
'initiative' is the definition.
('enterprise' can be a synonym of 'initiative')
'to go in and pry' is the wordplay.
'to go in' becomes 'enter' ('enter' can be a synonym of 'go in').
'and' means one lot of letters go next to another.
'pry' becomes 'prise' ('prise' can be a synonym of 'pry').
'enter'+'prise'='ENTERPRISE'
'required' acts as a link.
(Other definitions for enterprise that I've seen before include "Bold resourcefulness" , "Plan" , "Company" , "business concern" , "New project" .)