Insanely angered, leading to anger (7)
I believe the answer is:
derange
'anger' is the definition.
'insanely angered' is the wordplay.
'insanely' is an anagram indicator.
'angered' is an anagram of 'DERANGE'.
'leading to' is the link.
(Other definitions for derange that I've seen before include "Make insane" , "Unhinge" , "Madden" , "Remove from order" , "Upset" .)