Insect queen (6)
I believe the answer is:
mother
'insect queen' is the definition.
The answer and definition can be both people as well as being singular nouns.
Perhaps you can see an association between them that I don't see?
'insect queen' is the wordplay.
'insect' becomes 'moth' (moth is a kind of insect).
'queen' becomes 'ER' (abbreviation for Elizabeth Regina).
'moth'+'er'='MOTHER'
(Other definitions for mother that I've seen before include "Fuss over" , "Female parent" , "Dam" , "- - 7 across, pantomime" , "Parent to her Tom, oddly" .)