Instrument famous priest treated with disrespect (8)
I believe the answer is:
violated
'treated with disrespect' is the definition.
I can't judge whether this definition defines the answer.
'instrument famous priest' is the wordplay.
'instrument' becomes 'viola' (viola is a kind of instrument).
'famous priest' becomes 'ted' (I can't explain this - if you can you should give a lot more credence to this answer).
'viola'+'ted'='VIOLATED'
Can you help me to learn more?
(Other definitions for violated that I've seen before include "Desecrated sacred place of dovetail." , "Treated irreverently or sacrilegiously" , "Broken" , "Abused" , "Defiled" .)