Instrument made in red and orange, strangely (4,5)
I believe the answer is:
reed organ
'instrument' is the definition.
(I know that reed organ is a type of instrument)
'red and orange strangely' is the wordplay.
'and' is a charade indicator (letters next to each other).
'strangely' indicates an anagram.
'red' after 'orange' is 'orangered'.
'orangered' anagrammed gives 'REED-ORGAN'.
'made in' acts as a link.
(Other definitions for reed organ that I've seen before include "supports traditional services" , "Keyboard instrument, harmonium" , "What you might hear" , "musical instrument" , "Melody Maker?" .)