Instrument with heavy end grasping female (5)
I believe the answer is:
harpy
'female' is the definition.
(I know that Harpy is a type of female)
'instrument with heavy end grasping' is the wordplay.
'instrument' becomes 'harp' (harp is a kind of instrument).
'with heavy end grasping' becomes 'y' (I can't explain this - if you can you should believe this answer much more).
'harp'+'y'='HARPY'
Can you help me to learn more?
(Other definitions for harpy that I've seen before include "Greedy woman" , "Filthy beast" , "Ravenous monster -- nagging woman" , "Bad-tempered woman" , "Rapacious woman-bird" .)