International politician died after drink spiked (7)
I believe the answer is:
impaled
'spiked' is the definition.
('impale' can be a synonym of 'spike')
'international politician died after drink' is the wordplay.
'international' becomes 'i' (abbreviation eg in IMF).
'politician' becomes 'mp'.
'died' becomes 'd'.
'after' means one lot of letters go next to another.
'drink' becomes 'ale' (ale is a kind of drink**).
'd' after 'ale' is 'aled'.
'i'+'mp'+'aled'='IMPALED'
(Other definitions for impaled that I've seen before include "Pierced as with a stick or stake" , "Pierced through in mid-leap" , "Transfixed" , "killed for a vampire" , "Stuck" .)