International young lady drinking shot (6)
I believe the answer is:
global
'international' is the definition.
(similar in meaning)
'young lady drinking shot' is the wordplay.
'young lady' becomes 'gal' (synonyms).
'drinking' indicates putting letters inside (inserted letters are consumed or drunk).
'shot' becomes 'lob' (type of shot in eg tennis).
'gal' enclosing 'lob' is 'GLOBAL'.
(Other definitions for global that I've seen before include "Affecting the whole world" , "Universal" , "Sphere-shaped" , "all over the place" , "international" .)