Invigorate Frenchman with touch of wine (5)
I believe the answer is:
renew
'invigorate' is the definition.
(thesaurus)
'frenchman with touch of wine' is the wordplay.
'frenchman' becomes 'rene'.
'with' is a charade indicator (letters next to each other).
'touch of' says to take the initial letters.
The first letter of 'wine' is 'w'.
'rene'+'w'='RENEW'
(Other definitions for renew that I've seen before include "Start afresh" , "Regenerate" , "Restore, resume" , "Make afresh" , "Reinforce" .)