Irksome one (4)

I believe the answer is:

pest

'irksome one' is the definition.
(I've seen this in another clue)

This is all the clue.

(Other definitions for pest that I've seen before include "Disease with a high death rate" , "Troublesome man or animal" , "Annoying creature" , "Annoyance" , "Annoying person" .)

I've seen this clue in the Newsday and the LA Times.

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