Irritable as spirit diluted (5-8)
I believe the answer is:
short-tempered
'irritable' is the definition.
(I've seen this before)
'spirit diluted' is the wordplay.
'spirit' becomes 'short' (I am not sure about this - if you are sure you should believe this answer much more).
'diluted' becomes 'tempered' (similar in meaning).
'short'+'tempered'='SHORT-TEMPERED'
'as' acts as a link.
Can you help me to learn more?
(Other definitions for short-tempered that I've seen before include "Easily riled" , "Impatient" , "Easily moved to anger" , "Irascible" , "Tending to anger quickly" .)