Irritable or unwell (3,2,5)
I believe the answer is:
out of sorts
I believe this clue is a double definition.
'irritable' is the first definition.
(I've seen this before)
'unwell' is the second definition.
(thesaurus)
(Other definitions for out of sorts that I've seen before include "Lacking variety" , "Irritable" , "Slightly unhappy" , "Slightly unwell" , "Not well" .)