Irritate or displease (5)
I believe the answer is:
annoy
I believe this is a double definition.
'irritate' is the first definition.
(I know that irritate can be written as annoy)
'displease' is the second definition.
(I know that annoy is a kind of displease)
(Other definitions for annoy that I've seen before include "Displease" , "Upset" , "Irritate, nettle" , "trouble" , "Make slightly angry" .)