Irritate, with weed say? (6)
I believe the answer is:
nettle
This clue might be a double definition.
'irritate' is the first definition.
(I know that irritate can be written as nettle)
'weed say?' is the second definition.
'nettle' can be an answer for 'weed' (I've seen this before). I am not sure about the 'say?' bit.
'with' acts as a link.
Can you help me to learn more?
(Other definitions for nettle that I've seen before include "Bug" , "To be annoying" , "Annoy; common weed" , "Upset" , "Irritate, annoy" .)