Irritating and spiteful — not British (5)
I believe the answer is:
itchy
'irritating' is the definition.
(an itch is irritating)
'spiteful not british' is the wordplay.
'spiteful' becomes 'bitchy' (informal term).
'not' is a deletion indicator.
'british' becomes 'b' (abbreviation e.g. in 'BBC').
'bitchy' with 'b' taken out is 'ITCHY'.
'and' acts as a link.
(Other definitions for itchy that I've seen before include "Tingling - desirous" , "Like the feet of the restless" , "Making one want to scratch" , "Affected by skin irritation" , "Fidgety" .)