Irritating pong around different things modiste cleared out (10)
I believe the answer is:
bothersome
'irritating' is the definition.
(I've seen this before)
'pong around different things modiste cleared out' is the wordplay.
'pong' becomes 'BO' (body odour).
'around' means one lot of letters goes inside another.
'different things' becomes 'others'.
'cleared out' says to hollow out the word (remove centre letters).
'modiste' with its centre removed is 'me'.
'bo' placed around 'others' is 'botherso'.
'botherso'+'me'='BOTHERSOME'
(Other definitions for bothersome that I've seen before include "Trying" , "Irritating" , "Annoying" , "A pain" , "Perplexing" .)