Irritation in Georgia — lie low at the outset (4)
I believe the answer is:
gall
'irritation' is the definition.
(I've seen this in other clues)
'georgia lie low at the outset' is the wordplay.
'georgia' becomes 'GA' (abbreviation).
'at the outset' says to take the initial letters (the outset is the beginning).
The first letters of 'lie low' is 'll'.
'ga'+'ll'='GALL'
'in' is the link.
(Other definitions for gall that I've seen before include "Rancour; a fungal growth" , "Liver's secretion" , "A sore spot or a bodily bladder" , "Impertinence" , "Bitterness of feeling or bodily bladder" .)