Irritation of one in short sleepover (4)
I believe the answer is:
pain
'irritation' is the definition.
(thesaurus)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for pain that I've seen before include "nuisance to be put up with" , "Suffering of body or mind" , "Mental distress" , "Symptom of hurt or disorder" , "Unpleasant sensation" .)