Is depressed about, when you repudiate (6)
I believe the answer is:
disown
'repudiate' is the definition.
(I know that repudiate can be written as disown)
'is depressed about' is the wordplay.
'depressed' becomes 'down' (synonyms).
'about' means one lot of letters goes inside another.
'is' going within 'down' is 'DISOWN'.
'when you' is the link.
I am not very happy about this link. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for disown that I've seen before include "Refuse to be connected with" , "Repudiate or refuse to acknowledge a relationship" , "Refuse responsibility for" , "Reject all connection with, refuse to acknowledge" , "Wins do (anag)" .)