Is it strange in tone? (4)
I believe the answer is:
note
'tone?' is the definition.
('note' can be a synonym of 'tone')
'is it strange in' is the wordplay.
'is it' becomes 't' (abbreviation. e.g. in 'tis).
'strange' becomes 'noe' (I can't explain this - if you can you should believe this answer much more).
'in' indicates putting letters inside.
't' inserted within 'noe' is 'NOTE'.
Can you help me to learn more?
(Other definitions for note that I've seen before include "Short communication" , "Brief letter - distinction" , "Short personal letter" , "Sound, record" , "A piece of paper money" .)