Crossword Genius

Is of a different city (5)

Ross

I believe the answer is:

sofia

'city' is the definition.
(I know that Sofia is a city)

'is of a different' is the wordplay.
'different' is an anagram indicator (letters placed in a different order).
'is'+'of'+'a'='isofa'
'isofa' is an anagram of 'SOFIA'.

(Other definitions for sofia that I've seen before include "Bulgarian city" , "seat of government" , "Foreign city" , "Bulgarian capital" , "capital city" .)

I've seen this clue in the Evening Standard.
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