Is sick of extremely tough arguments over university parking (6,2)

'is sick' is the definition.
('throw up' can be a synonym of 'be sick')

'extremely tough arguments over university parking' is the wordplay.
'extremely' says to hollow out the word (remove centre letters) (only the extremes of the word are used).
'arguments' becomes 'rows' (I've seen this before).
'over' says to put letters next to each other (in a down clue, some letters go over others).
'university' becomes 'U' (abbreviation for university).
'parking' becomes 'p' (abbreviation on road signs).
'tough' with its middle removed is 'th'.
'th'+'rows'+'u'+'p'='THROWS UP'

'of' is the link.