Is unfaithful. See the lady is getting the run-around (8)
I believe the answer is:
disloyal
'is unfaithful' is the definition.
(associated in meaning)
'see the lady is getting the run-around' is the wordplay.
'see' becomes 'lo' (archaic exclamation meaning 'look!').
'getting' means one lot of letters go next to another.
'the run' indicates an anagram.
'around' indicates putting letters inside.
'lady'+'is'='ladyis'
'ladyis' anagrammed gives 'disyal'.
'lo' inserted into 'disyal' is 'DISLOYAL'.
(Other definitions for disloyal that I've seen before include "Not faithful, unpatriotic" , "Deserting allegiance or duty" , "Deserting one's allegiance" , "Not true or faithful in one's relationships" , "Unfaithful or unpatriotic" .)