Crossword Genius

Isaac Newton, from the age of 62 onward (3)

Ross

I believe the answer is:

sir

(Other definitions for sir that I've seen before include "Title for knight or teacher" , "Male title of respect" , "Respectful address for a man" , "Formal term of address" , "Term of address for a gentleman" .)

I've seen this clue in The New York Times.
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