___ Island (setting of John Updike's novel "The Witches of Eastwick") (5)
I believe the answer is:
rhode
(Other definitions for rhode that I've seen before include ". . . . . Island is state of USA" , "US state . . . . . Island" , "Smallest state of the USA" , ". . . . . Island, state in New England" , "This Island is a small American state" .)