Islands that are East or West, mostly free from big business (5)
I believe the answer is:
indie
'islands that are east or west mostly free' is the definition.
I know nothing about this answer so I can't judge whether this works.
'from big business' is the wordplay.
'from' becomes 'in' (I've seen this in other clues).
'big business' becomes 'die' (I can't explain this - if you can you should believe this answer much more).
'in'+'die'='INDIE'
Can you help me to learn more?
(Other definitions for indie that I've seen before include "paper" , "Not signed up to a major record company" , "Specialist record company" , "Non-mainstream film company" , "(Pop group) not affiliated with a major record company" .)