Crossword Genius

Isolate mutant rat genes (8)

Ross

I believe the answer is:

estrange

'isolate' is the definition.
(thesaurus)

'mutant rat genes' is the wordplay.
'mutant' indicates anagramming the letters.
'rat'+'genes'='ratgenes'
'ratgenes' is an anagram of 'ESTRANGE'.

(Other definitions for estrange that I've seen before include "drive apart" , "Drive away" , "Get on the wrong side of" , "Arouse hostility" , "Ten gears (anag.)" .)

I've seen this clue in The Independent.
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