Isolated workers finally quit accommodation (9)
I believe the answer is:
apartment
'accommodation' is the definition.
(I've seen this before)
'isolated workers finally quit' is the wordplay.
'isolated' becomes 'apart' (synonyms).
'workers' becomes 'men' (men can mean staff or employees).
'finally' indicates one should take the final letters.
The final letter of 'quit' is 't'.
'apart'+'men'+'t'='APARTMENT'
(Other definitions for apartment that I've seen before include "Room ? flat" , "19 across" , "Set of rooms or American flat" , "Suite of rooms to live in" , "Flat (chiefly US)" .)