Issue a note to me and Reg, possibly (6)
I believe the answer is:
emerge
'issue' is the definition.
('emerge' can be a synonym of 'issue')
'a note to me and reg possibly' is the wordplay.
'a note' becomes 'e' (musical note**).
'to' says to put letters next to each other (I've seen this in other clues).
'and' means one lot of letters go next to another (I've seen this in other clues).
'possibly' indicates anagramming the letters.
'me' put after 'reg' is 'regme'.
'regme' with letters rearranged gives 'emerg'.
'e' after 'emerg' is 'EMERGE'.
(Other definitions for emerge that I've seen before include "Break out (from an egg)" , "Move out and become visible" , "Come to light" , "Come into greater prominence" , "Become gradually apparent" .)