Issue a note to me and Reg, possibly (6)
I believe the answer is:
emerge
'issue' is the definition.
(issue can mean to emerge or appear)
'a note to me and reg possibly' is the wordplay.
'a note' becomes 'e' (musical note).
'to' means one lot of letters go next to another (I've seen this in other clues).
'and' says to put letters next to each other.
'possibly' is an anagram indicator.
'me' put after 'reg' is 'regme'.
'regme' anagrammed gives 'emerg'.
'e' after 'emerg' is 'EMERGE'.
(Other definitions for emerge that I've seen before include "Break out (from an egg)" , "Move out and become visible" , "Come to light" , "Come into greater prominence" , "Become gradually apparent" .)