Issue arising from issue? (13)
I believe the answer is:
grandchildren
'issue' is the definition.
(thesaurus)
'arising from issue?' is the wordplay.
'arising from' becomes 'grand' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'issue?' becomes 'children' (I've seen this before).
'grand'+'children'='GRANDCHILDREN'
Can you help me to learn more?
(Other definitions for grandchildren that I've seen before include "Junior members of family" , "relatives" , "Offspring of one's offspring" .)