Issue containing upside-down image is free (10)
I believe the answer is:
emancipate
'is free' is the definition.
(I've seen this before)
'issue containing upside-down image' is the wordplay.
'issue' becomes 'emanate' (I've seen this before).
'containing' means one lot of letters goes inside another.
'upside down' is a reversal indicator.
'image' becomes 'pic' (I've seen this before).
'pic' backwards is 'cip'.
'emanate' enclosing 'cip' is 'EMANCIPATE'.
(Other definitions for emancipate that I've seen before include "Free from slavery" , "setting free" , "release" , "Free from restrictions" , "Set free" .)