It can make a man hate what is repellent to him (8)
I believe the answer is:
anathema
'is repellent to him' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'it can make a man hate' is the wordplay.
'it can make' is an anagram indicator.
'a'+'man'+'hate'='amanhate'
'amanhate' anagrammed gives 'ANATHEMA'.
'what' is the link.
Can you help me to learn more?
(Other definitions for anathema that I've seen before include "hateful thing" , "thing we detest" , "Detested person or thing - excommunication" , "Curse; object of loathing" , "Bete noire" .)