It can make you fed up with a bit of a beating (6)
I believe the answer is:
defeat
'a beating' is the definition.
(thesaurus)
'it can make you fed up with a bit' is the wordplay.
'it' becomes 'e' ('e' can mean 'electronic' which is similar to 'IT').
'can make you' becomes 'fe' (I can't justify this - if you can you should give a lot more credence to this answer).
'fed' is an insertion indicator.
'up with' says the letters should be written backwards (move letters in down clue up).
'a bit' becomes 'tad' (both can mean a small amount).
'tad' back-to-front is 'dat'.
'e'+'fe'='efe'
'efe' going inside 'dat' is 'DEFEAT'.
'of' acts as a link.
Can you help me to learn more?
(Other definitions for defeat that I've seen before include "Win over, frustrate" , "Overwhelm" , "Trounce, beat" , "Opposite of victory" , "Loss" .)