It can't be made whole (6)
I believe the answer is:
intact
'whole' is the definition.
(similar in meaning)
'it can't be made' is the wordplay.
'be made' is an anagram indicator.
'it'+'cant'='itcant'
'itcant' is an anagram of 'INTACT'.
(Other definitions for intact that I've seen before include "Whole and complete" , "Entire and whole" , "Whole and undamaged" , "Perfect" , "All in one piece" .)