It causes pain and destruction (4)
I believe the answer is:
rack
'destruction' is the definition.
(rack is a kind of destruction)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for rack that I've seen before include "Storage frame; joint (of lamb)" , "Instrument of torture, stretched its victims" , "Rib section of lamb" , "Place of torture" , "associated with ruin" .)