It flows from the Alps to the Mediterranean (5)

I believe the answer is:

rhone

(Other definitions for rhone that I've seen before include "12 wine region" , "River running from the Swiss Alps to the Mediterranean" , "River running through France to the Med" , "River of Switzerland and France" , "River running through the city of Arles" .)

I've seen this clue in The New York Times.

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